Vitamin D3 for Self-Perceived Fatigue in Deficient Adults
Symptoms Studied
Persistent tiredness, low energy, feeling drained despite adequate sleep. Fatigue that interferes with daily activities and motivation.
Research Hypothesis
Vitamin D deficiency may contribute to fatigue through effects on muscle function, mitochondrial activity, and immune regulation. Correcting deficiency may restore energy levels.
Intervention Tested
Vitamin D3 (Cholecalciferol)
Single oral dose of 100,000 IU vitamin D3, administered at beginning of study
Study Results
Before Treatment
Otherwise healthy adults with vitamin D deficiency (serum 25(OH)D below 20 μg/L) reporting significant fatigue on standardized assessment scales.
After Treatment
Fatigue scores decreased by 29% in the vitamin D group versus only 13% in placebo. 72% of vitamin D group reported fatigue improvement compared to 50% in placebo group.
Timeline to Improvement
Improvements observed within 4 weeks of single high-dose treatment
Side Effects
Well-tolerated. No significant adverse events reported at this dose.
Source
- Vitamin D3 for Self-Perceived Fatigue in Deficient Adults
Nowak A, et al. Medicine (Baltimore). 2016;95(52):e5353
Conclusion
Vitamin D supplementation significantly reduces fatigue in otherwise healthy people with vitamin D deficiency, with over 70% experiencing improvement compared to 50% with placebo.
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