Saffron Extract for Mild to Moderate Depression
Symptoms Studied
Persistent low mood, loss of interest in activities, fatigue, difficulty concentrating, changes in sleep and appetite. Mild to moderate depressive symptoms affecting daily functioning.
Research Hypothesis
Saffron's bioactive compounds (crocin, crocetin, safranal) may have antidepressant effects through modulation of serotonin, dopamine, and norepinephrine neurotransmitter systems.
Intervention Tested
Saffron (Crocus sativus) Extract
30mg saffron petal extract daily, standardized to bioactive compounds, taken in divided doses
Study Results
Before Treatment
Adults with mild to moderate depression diagnosed using standardized criteria, not on antidepressant medication.
After Treatment
Saffron showed large effect size vs placebo (ES=1.62, p<0.001) in reducing depressive symptoms. 72% of saffron group achieved clinically significant improvement compared to 54% placebo.
Timeline to Improvement
Improvements observed within 2-4 weeks, with continued benefit through 6 weeks
Side Effects
Generally well-tolerated. Occasional mild headache, nausea, or anxiety reported in some patients.
Source
- Saffron Extract for Mild to Moderate Depression
Akhondzadeh S, et al. Phytother Res. 2005;19(2):148-151
Conclusion
Saffron extract demonstrates significant antidepressant effects in mild to moderate depression, with efficacy comparable to conventional antidepressants in head-to-head trials.
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