Lion's Mane Mushroom for Mild Cognitive Impairment
Symptoms Studied
Mental cloudiness, difficulty concentrating, forgetfulness, slower thinking, and trouble finding words. Mild cognitive decline affecting daily tasks.
Research Hypothesis
Lion's mane contains compounds that may stimulate nerve growth factor (NGF) production, potentially supporting brain health and cognitive function.
Intervention Tested
Hericium erinaceus (Lion's Mane) Extract
Four 250mg tablets containing 96% Yamabushitake (lion's mane) dry powder, taken three times daily (3g total)
Study Results
Before Treatment
Adults aged 50-80 with diagnosed mild cognitive impairment, showing reduced scores on cognitive function assessments.
After Treatment
Cognitive function scores were significantly higher in the mushroom group at weeks 8, 12, and 16 compared to placebo. Scores declined 4 weeks after stopping supplementation.
Timeline to Improvement
Improvements observed by week 8, with continued benefit through week 16. Effects reversed after discontinuation.
Side Effects
No adverse effects observed during laboratory testing. Well-tolerated.
Source
- Lion's Mane Mushroom for Mild Cognitive Impairment
Mori K, et al. Phytother Res. 2009;23(3):367-372
Conclusion
Lion's mane mushroom improves cognitive function in adults with mild cognitive impairment, though benefits appear to require continued supplementation to maintain.
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