Boswellia Serrata Extract for Knee Osteoarthritis
Symptoms Studied
Knee pain, stiffness, and reduced mobility due to osteoarthritis. Pain worsens with activity and may limit daily activities like walking and climbing stairs.
Research Hypothesis
Boswellic acids, particularly AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), inhibit 5-lipoxygenase enzyme, reducing inflammatory leukotrienes and joint inflammation.
Intervention Tested
Boswellia Serrata Extract
333mg Boswellia serrata extract three times daily (approximately 1g total), standardized to boswellic acid content
Study Results
Before Treatment
Adults with clinically diagnosed knee osteoarthritis experiencing moderate pain, stiffness, and functional limitations.
After Treatment
Significant improvement in VAS pain score (WMD -8.33, p<0.00001). Reduced stiffness and improved physical function. Benefits visible as early as 5 days after starting.
Timeline to Improvement
Rapid onset with benefits noticeable within first week; maximum effect by 8-12 weeks
Side Effects
Generally well-tolerated. Occasional mild GI symptoms (diarrhea, nausea). No serious adverse events in clinical trials.
Source
- Boswellia Serrata Extract for Knee Osteoarthritis
Kimmatkar N, et al. Phytomedicine. 2003;10(1):3-7
Conclusion
Boswellia serrata extract is an effective, safe anti-inflammatory option for knee osteoarthritis with rapid onset of action.
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